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KMID : 0378019940370050091
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New Medical Journal
1994 Volume.37 No. 5 p.91 ~ p.96
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Clinical effect of Cefuroxime axetil in bacterial sinusitis
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Abstract
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Cefuroxime axetil is an oral pro-drug of cefuroxime, a second generation cephalosporin with a broad spectrum of antibacterial activity, including penicillinase and beta-lactamase producing bacteria.
Cefuroxime axetil when given orally produces high prolonged serum levels of cefuroxime. The concentration in the CSF is about 10% of the level in serum.
43 patients with bacterial sinusitis took cefuroxime axetil 250mg twice daily by mouth and the following results were obtainedNo bacterial growth in 88%(33/43) of patients after 8-10 days of treatment,
-72% were clinically free of symptoms after 8-10 days and 95% after 16-18 days of treatment
-No side effects were noted during the study
On the basis of this study, we conclude that cefuroxime axetil is an effective antibiotic for the treatment of bacterial sinusitis.
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